Extrahepatic lipid synthesis

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Extrahepatic synthesis of apolipoprotein E.

Apolipoprotein E (apoE) synthesis has been examined in rat and guinea pig tissues using in vitro translation and [35S]methionine labeling of tissue slices. A number of tissues not involved in lipoprotein synthesis synthesize a protein very similar to apoE, including the spleen, adrenal, kidney, testis, ovary, heart, and lung. Although the intestine is involved in lipoprotein synthesis, apoE syn...

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Synthesis of hepatic lipase in liver and extrahepatic tissues1

Immunoprecipitations of hepatic lipase from pulselabeled rat liver have demonstrated that hepatic lipase is synthesized in two distinct molecular weight forms, HL-I (M, = 51,000) and HL-I1 (M, = 53,000). Both forms are immunologically related to purified hepatic lipase, but not to lipoprotein lipase. HL-I and HL-11 are also kinetically related and represent different stages of intracellular pro...

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Synthesis of hepatic lipase in liver and extrahepatic tissues.

Immunoprecipitations of hepatic lipase from pulse-labeled rat liver have demonstrated that hepatic lipase is synthesized in two distinct molecular weight forms, HL-I (Mr = 51,000) and HL-II (Mr = 53,000). Both forms are immunologically related to purified hepatic lipase, but not to lipoprotein lipase. HL-I and HL-II are also kinetically related and represent different stages of intracellular pr...

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Extrahepatic synthesis of factor VII in human atherosclerotic vessels.

OBJECTIVE Coagulation is initiated by the interaction of tissue factor (TF) with plasma coagulation factors VII (FVII) and X (FX). TF is highly expressed in atherosclerotic lesions, but little is known about the synthesis of FX or FVII outside of the liver. Previous studies suggested that macrophages synthesize FVII. We therefore hypothesized that macrophages within atherosclerotic lesions may ...

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Choline biosynthesis in sheep. Evidence for extrahepatic synthesis.

1. Choline production by various tissues of the sheep was measured by determining venous and arterial free choline concentrations in blood samples taken from various vessels in conscious multicannulated sheep. 2. Significant production of free choline occurred in the upper and lower body regions, and specifically in the heart, brain and hind-limb muscles of sheep, but there was no significant u...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1950

ISSN: 0306-3283

DOI: 10.1042/bj0470233